ABSTRACT
OBJECTIVE:To provide reference for the rational application of antimicrobial drugs. METHODS:Medical records of all acute exacerbation of chronic obstructive pulmonary disease(AECOPD)hospitalized patients were collected from respiration department of our hospital during Sept. 2013 to Apr. 2014 and May 2014 to Dec. 2014,73 and 88 cases respectively. The applica-tion of antimicrobial drug was analyzed comparatively,and the rationality of drug use in AECOPD patients was evaluated. RE-SULTS:After the special rectification activities,the antimicrobial use intensity dropped from 217.74 to 91.58;drug combination rate dropped from 67.12% to 6.82%;no reason to change the antimicrobials conditions dropped from 15.07% to 0;hospital stay shortened from(10.21±3.44)d to(7.13±3.14)d;the total cost of medical treatment dropped from(6 117.73±1 164.52)yuan to (4 574.82±997.28)yuan;percentage of medicine expenses and antimicrobial drug expenses dropped from(61.83±11.49)% and (28.84±9.55)% to(43.52±9.97)% and(20.07±6.43)%,respectively;there was statistical significance(P<0.05),and the clinical treatment effect were uninfluenced. CONCLUSIONS:The special rectification activities of antimicrobial drugs could effec-tively improve the rational application of antimicrobial drugs and enhance the efficacy of antimicrobial drugs and decrease the cost of drug use.